argatroban dosing calculator
Stopping this drug too early could result in a lapse in therapeutic anticoagulation. When initiated argatroban should be dosed the same in those with HITT and isolated HIT.
Argatroban Versus Heparin In Patients Without Heparin Induced Thrombocytopenia During Venovenous Extracorporeal Membrane Oxygenation A Propensity Score Matched Study Springerlink
Hepatic dosing anticoagulation Child-Pugh Class A.
. Therapeutic Goal Range for PTT is 55-100. Argatroban interferes with the INR assay. Initiate an infusion of Argatroban in Sodium Chloride Injection at 25 mcgkgmin and administer a bolus of 350 mcgkg via a large bore intravenous line over 3 to 5 minutes see.
Standard Argatroban Infusion is 250mg in Normal Saline 250mL yielding a concentration of 1 mgmL or 1000 mcgmL. Procedure may proceed if ACT is 300. The optimal range for argatroban is APTT ratio 15 - 30 Standard dosing schedule Initial infusion rate 2 microgramskgmin Critically ill or hepatically impaired patients Initial infusion rate 05.
Dosing and titrating argatroban. Argatroban is a a small molecule synthetic direct thrombin inhibitor. It is a direct thrombin.
Other fields are output only. Obtain an activated clotting time ACT 5 to 10 minutes after the bolus dose is completed. If argatroban therapy is used concurrently with or following FFP or a thrombolytic some centers decrease dose by half.
Argatroban dosing in obesity Obese patients require similar median argatroban maintenance doses when compared to non-obese patients. Get the Vancomycin Dosing Calculator - A. 2 OR 4 for patients with primary biliary cirrhosis 1 point 2-3 OR 4-10 for patients with primary biliary cirrhosis 2.
This program allows for multiple selections. Prediction errors for monotherapy INRs were or - 04 for. Relationship at Steady State Between Argatroban Dose Plasma Argatroban.
A bolus of 350 mcgkg IV over 3-5 minutes via large-bore IV line Check activated clotting time ACT 5-10 minutes after bolus dose is completed. Shown below for Argatroban infusion doses up to 10 mcgkgmin see Figure 1. Co-therapy INR increased linearly with monotherapy INR with slope sensitive to argatroban dose and thromboplastin used.
Obtain ACTs before dosing 5 to 10 minutes after bolus dosing following. Infusion Rate Calculator Use the tab key to navigate the form. However in icu patients particularly when multiorgan failure exists the starting dose of argatroban has to be reduced to 05 to 10 µg kg 1 min 1 and particularly during the initial.
Required data entry fields are teal in color. The dose for heparin-induced thrombocytopenia without hepatic impairment is 2 mcgkgmin administered as a continuous infusion 21 Discontinue heparin therapy and obtain a. It is a useful tool to determine the rate of pump medication infusion to achieve therapeutic dosing.
Doses 2 mcgkgmin Temporarily reduce dose of argatroban to 2 mcgkgmin in order to predict INR on warfarin alone Repeat INR 4 to 6 hours after reduction and follow the process outlined. Select Drug and Concentration For medications that are. Formula Composition Depending on units selected the general composition for the.
Based on these results argatroban should be. Child-Pugh Class B or C. To pick and choose one drug at a time hold down the ctrl key and make as many selections as you need.
It is used as an alternative anticoagulant in patients with heparin-induced thrombocytopenia HIT. Argatroban is a medication used to manage heparin-induced thrombocytopenia HIT which is a rare life-threatening complication of heparin therapy. 100 mcgkg iv bolus followed by either low-dose 1 mcgkgminute continuous iv infusion or high-dose 3 mcgkgminute continuous iv infusion argatroban was compared to heparin 70.
Hepatic Disease Score Calculator for Argatroban Dosing. Start 05 mcgkgmin titrate slowly. Start dose amount not defined titrate slowly.
Maximum dose 10mcgkgmin Switching to warfarin.
Jcm Free Full Text A Prospective Pilot Trial To Assess The Efficacy Of Argatroban Argatra In Critically Ill Patients With Heparin Resistance Html
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Argatroban Argatroban Injection Uses Dosage Side Effects Interactions Warning
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Argatroban Argatroban Injection Uses Dosage Side Effects Interactions Warning
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